FARS2

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FARS2
Protein FARS2 PDB 3CMQ.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FARS2, COXPD14, FARS1, HSPC320, PheRS, dJ520B18.2, phenylalanyl-tRNA synthetase 2, mitochondrial, SPG77
External IDs MGI: 1917205 HomoloGene: 4788 GeneCards: FARS2
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FARS2
Genomic location for FARS2
Band No data available Start 5,261,044 bp[1]
End 5,771,580 bp[1]
RNA expression pattern
PBB GE FARS2 204283 at fs.png

PBB GE FARS2 204282 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006567
NM_001318872

NM_001039189
NM_024274

RefSeq (protein)

NP_001305801
NP_006558

NP_001034278
NP_077236

Location (UCSC) Chr 6: 5.26 – 5.77 Mb Chr 6: 36.12 – 36.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phenylalanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the FARS2 gene.[5][6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145982 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021420 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bullard JM, Cai YC, Demeler B, Spremulli LL (Jun 1999). "Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase". J Mol Biol. 288 (4): 567–77. PMID 10329163. doi:10.1006/jmbi.1999.2708. 
  6. ^ a b "Entrez Gene: FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial". 

Further reading[edit]