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Fas-activated serine/threonine kinase
Symbols FASTK ; FAST
External IDs OMIM606965 MGI1913837 HomoloGene4884 GeneCards: FASTK Gene
EC number
RNA expression pattern
PBB GE FASTK 214114 x at tn.png
PBB GE FASTK 202676 x at tn.png
PBB GE FASTK 210975 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10922 66587
Ensembl ENSG00000164896 ENSMUSG00000028959
UniProt Q14296 Q9JIX9
RefSeq (mRNA) NM_001258461 NM_023229
RefSeq (protein) NP_001245390 NP_075718
Location (UCSC) Chr 7:
151.08 – 151.08 Mb
Chr 5:
24.44 – 24.45 Mb
PubMed search [1] [2]

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.[3]


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