FASTK

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FASTK
Identifiers
Aliases FASTK, Fastk, 0610011K02Rik, 610011K02Rik, FAST, Fas activated serine/threonine kinase
External IDs MGI: 1913837 HomoloGene: 4884 GeneCards: FASTK
RNA expression pattern
PBB GE FASTK 210975 x at fs.png

PBB GE FASTK 202676 x at fs.png

PBB GE FASTK 214114 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258461
NM_006712
NM_033015

NM_023229

RefSeq (protein)

NP_001245390
NP_006703
NP_148936

n/a

Location (UCSC) Chr 7: 151.08 – 151.08 Mb Chr 5: 24.44 – 24.45 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[3][4][5]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.[5]

References[edit]

Further reading[edit]