FAT4

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FAT4
Identifiers
Aliases FAT4, CDHF14, CDHR11, FAT-J, FATJ, NBLA00548, VMLDS2, HKLLS2, FAT atypical cadherin 4
External IDs MGI: 3045256 HomoloGene: 14377 GeneCards: FAT4
Genetically Related Diseases
bipolar disorder, major depressive disorder[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291285
NM_001291303
NM_024582

NM_183221

RefSeq (protein)

NP_001278214
NP_001278232
NP_078858
NP_001278214.1
NP_001278232.1

NP_899044.3
NP_899044

Location (UCSC) Chr 4: 125.32 – 125.49 Mb Chr 3: 38.89 – 39.01 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.[4][5]

FAT4 is associated with the Hippo signaling pathway.[6]

Clinical significance[edit]

Mutations in FAT4 are associated to Hennekam syndrome .[7]

References[edit]

  1. ^ "Diseases that are genetically associated with FAT4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)". 
  5. ^ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449. 
  6. ^ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156Freely accessible. PMID 19048595. 
  7. ^ Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics. 133: 1161–1167. doi:10.1007/s00439-014-1456-y. PMID 24913602. 

Further reading[edit]