FBLIM1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FBLIM1
Protein FBLIM1 PDB 2K9U.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FBLIM1, CAL, FBLP-1, FBLP1, filamin binding LIM protein 1
External IDs MGI: 1921452 HomoloGene: 56774 GeneCards: FBLIM1
RNA expression pattern
PBB GE FBLIM1 gnf1h06896 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024215
NM_001024216
NM_017556
NM_001350151

NM_001163256
NM_133754

RefSeq (protein)

NP_001019386
NP_001019387
NP_060026
NP_001337080

NP_001156728.1
NP_598515.3
NP_001156728
NP_598515

Location (UCSC) Chr 1: 15.76 – 15.79 Mb Chr 4: 141.58 – 141.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.[3][4][5]

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

Interactions[edit]

FBLIM1 has been shown to interact with Filamin,[6] PLEKHC1[3] and FLNB.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. 
  4. ^ Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS (March 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J Biol Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242. 
  5. ^ a b "Entrez Gene: FBLIM1 filamin binding LIM protein 1". 
  6. ^ Tu, Yizeng; Wu Shan; Shi Xiaohua; Chen Ka; Wu Chuanyue (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. United States. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. ISSN 0092-8674. PMID 12679033. 
  7. ^ Takafuta, Toshiro; Saeki Mari; Fujimoto Tetsuro-Takahiro; Fujimura Kingo; Shapiro Sandor S (April 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J. Biol. Chem. United States. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. ISSN 0021-9258. PMID 12496242. 

Further reading[edit]