FBXL5

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FBXL5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FBXL5, FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5
External IDs MGI: 2152883 HomoloGene: 8129 GeneCards: FBXL5
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for FBXL5
Genomic location for FBXL5
Band 4p15.32 Start 15,604,539 bp[1]
End 15,681,679 bp[1]
RNA expression pattern
PBB GE FBXL5 209004 s at fs.png

PBB GE FBXL5 209005 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193534
NM_001193535
NM_012161

NM_001159963
NM_178729

RefSeq (protein)

NP_001180463
NP_001180464
NP_036293

NP_001153435
NP_848844

Location (UCSC) Chr 4: 15.6 – 15.68 Mb Chr 4: 43.74 – 43.82 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.[5][6]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.[6]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118564 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039753 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  6. ^ a b "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5". 

Further reading[edit]