FBXO5

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FBXO5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5
RNA expression pattern
PBB GE FBXO5 218875 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142522
NM_012177

NM_025995

RefSeq (protein)

NP_001135994
NP_036309

NP_080271.2
NP_080271

Location (UCSC) Chr 6: 152.97 – 152.98 Mb Chr 10: 5.8 – 5.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.[3][4][5]

Function[edit]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.[5]

Interactions[edit]

FBXO5 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  4. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  5. ^ a b "Entrez Gene: FBXO5 F-box protein 5". 
  6. ^ a b Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. 
  7. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 

Further reading[edit]