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Protein FCAR PDB 1ovz.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases FCAR, CD89, CTB-61M7.2, FcalphaRI, Fc fragment of IgA receptor
External IDs HomoloGene: 48064 GeneCards: 2204
RNA expression pattern
PBB GE FCAR 211307 s at tn.png

PBB GE FCAR 211816 x at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 19: 54.87 – 54.89 Mb n/a
PubMed search [1] n/a
View/Edit Human

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene.[2]


This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.[2]


FCAR has been shown to interact with FCGR1A.[3]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ a b "Entrez Gene: FCAR Fc fragment of IgA, receptor for". 
  3. ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (December 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". J. Biol. Chem. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.