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Fc fragment of IgA, receptor for
Protein FCAR PDB 1ovz.png
PDB rendering based on 1ovz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCAR ; CD89
External IDs OMIM147045 HomoloGene48064 GeneCards: FCAR Gene
RNA expression pattern
PBB GE FCAR 211307 s at tn.png
PBB GE FCAR 211816 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2204 n/a
Ensembl ENSG00000186431 n/a
UniProt P24071 n/a
RefSeq (mRNA) NM_002000 n/a
RefSeq (protein) NP_001991 n/a
Location (UCSC) Chr 19:
55.39 – 55.4 Mb
PubMed search [1] n/a

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene.[1]


This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.[1]


FCAR has been shown to interact with FCGR1A.[2]

See also[edit]


  1. ^ a b "Entrez Gene: FCAR Fc fragment of IgA, receptor for". 
  2. ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ et al. (December 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". J. Biol. Chem. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.