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Fc fragment of IgG, low affinity IIa, receptor (CD32)
Protein FCGR2A PDB 1fcg.png
PDB rendering based on 1fcg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCGR2A ; CD32; CD32A; CDw32; FCG2; FCGR2; FCGR2A1; FcGR; IGFR2
External IDs OMIM146790 MGI95500 HomoloGene47936 ChEMBL: 5841 GeneCards: FCGR2A Gene
RNA expression pattern
PBB GE FCGR2A 203561 at tn.png
PBB GE FCGR2A 210992 x at tn.png
PBB GE FCGR2A 211395 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2212 14131
Ensembl ENSG00000143226 ENSMUSG00000059498
UniProt P12318 P08508
RefSeq (mRNA) NM_001136219 NM_010188
RefSeq (protein) NP_001129691 NP_034318
Location (UCSC) Chr 1:
161.51 – 161.52 Mb
Chr 1:
171.05 – 171.06 Mb
PubMed search [1] [2]

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[1][2]


FCGR2A has been shown to interact with PIK3R1[3][4] and Syk.[4][5]

See also[edit]


  1. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735. 
  2. ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". 
  3. ^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. (UNITED STATES) 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888. 
  4. ^ a b Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta (NETHERLANDS) 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059. 
  5. ^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. (UNITED STATES) 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.