FCGR2A

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FCGR2A
Protein FCGR2A PDB 1fcg.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa
External IDs MGI: 95500 HomoloGene: 47936 GeneCards: FCGR2A
Genetically Related Diseases
Kawasaki disease, ulcerative colitis, systemic lupus erythematosus[1]
RNA expression pattern
PBB GE FCGR2A 203561 at tn.png

PBB GE FCGR2A 210992 x at tn.png

PBB GE FCGR2A 211395 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136219
NM_021642

NM_010188

RefSeq (protein)

NP_001129691
NP_067674

n/a

Location (UCSC) Chr 1: 161.51 – 161.52 Mb Chr 1: 171.05 – 171.06 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[4][5]


Interactions[edit]

FCGR2A has been shown to interact with PIK3R1[6][7] and Syk.[7][8]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with FCGR2A view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735. 
  5. ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". 
  6. ^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. UNITED STATES. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888. 
  7. ^ a b Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. NETHERLANDS. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059. 
  8. ^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. UNITED STATES. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.