FCGR2B

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FCGR2B
Protein FCGR2B PDB 1fcg.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb
External IDs MGI: 95499 HomoloGene: 2974 GeneCards: 2213
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001

NM_001077189
NM_010187

RefSeq (protein)

NP_034317.1

Location (UCSC) Chr 1: 161.66 – 161.68 Mb Chr 1: 170.96 – 170.98 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype.[1][2] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).


Function[edit]

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.[3] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.[4][5]

See also[edit]

References[edit]

  1. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735. 
  2. ^ "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)". 
  3. ^ Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082.  open access publication - free to read (Free full text)
  4. ^ Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681.  open access publication - free to read (Free full text)
  5. ^ Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299.  open access publication - free to read (Free full text)

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.