FCN2

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FCN2
Protein FCN2 PDB 2j0g.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases FCN2, EBP-37, FCNL, P35, ficolin-2, ficolin 2
External IDs HomoloGene: 3031 GeneCards: FCN2
RNA expression pattern
PBB GE FCN2 207804 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004108
NM_015837
NM_015838
NM_015839

n/a

RefSeq (protein)

NP_004099
NP_056652

n/a

Location (UCSC) Chr 9: 134.88 – 134.89 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene.[2][3]

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Endo Y, Sato Y, Matsushita M, Fujita T (Feb 1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics. 36 (3): 515–21. doi:10.1006/geno.1996.0497. PMID 8884275. 
  3. ^ a b "Entrez Gene: FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)". 

Further reading[edit]