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Protein FCN3 PDB 2j5z.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases FCN3, FCNH, HAKA1, ficolin 3
External IDs HomoloGene: 130523 GeneCards: FCN3
RNA expression pattern
PBB GE FCN3 205866 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 27.37 – 27.37 Mb n/a
PubMed search [1] n/a
View/Edit Human

Ficolin-3 is a protein that in humans is encoded by the FCN3 gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata.[2][3][4]

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem. 273 (33): 20721–7. doi:10.1074/jbc.273.33.20721. PMID 9694814. 
  3. ^ Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem. 47 (6): 777–86. doi:10.1177/002215549904700607. PMID 10330454. 
  4. ^ a b "Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)". 

Further reading[edit]