FC Twente played its first match 29 August 2007 in the newly founded Eredivisie's inaugural game, losing 2–3 against SC Heerenveen. It was also the first match of the Eredivisie in its inaugural season. The team ended in the bottom half of the table in its first three seasons, finishing 5th of 6 in 2008, 5th of 7 in 2009 and 4th of 6 in 2010. However, it won the national cup in 2008, beating FC Utrecht 3–1 in the final.
Twente won its second championship in its BeNe League debut, snatching the lead from Standard Liège with a last matchday 3–1 win. The Tukkers narrowly missed a double, losing the national cup's final on penalties against ADO Den Haag.