FER (gene)

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FER
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FER, FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3, p94-Fer, FER tyrosine kinase
External IDs MGI: 105917 HomoloGene: 74300 GeneCards: FER
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308028
NM_001308031
NM_001308038
NM_005246

NM_001037997
NM_001286415
NM_008000

RefSeq (protein)

NP_001294957
NP_001294960
NP_001294967
NP_005237

Location (UCSC) Chr 5: 108.75 – 109.2 Mb Chr 17: 63.9 – 64.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[3]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[3]

Interactions[edit]

FER (gene) has been shown to interact with TMF1[4] and Cortactin.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)". 
  4. ^ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. NETHERLANDS. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. 
  5. ^ Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. UNITED STATES. 273 (36): 23542–8. doi:10.1074/jbc.273.36.23542. ISSN 0021-9258. PMID 9722593. 

Further reading[edit]