FER (gene)

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FER
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFER, FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3, p94-Fer, FER tyrosine kinase
External IDsMGI: 105917 HomoloGene: 74300 GeneCards: FER
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for FER
Genomic location for FER
Band5q21.3Start108,747,822 bp[1]
End109,196,841 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308028
NM_001308031
NM_001308038
NM_005246

NM_001037997
NM_001286415
NM_008000

RefSeq (protein)

NP_001294957
NP_001294960
NP_001294967
NP_005237

NP_001033086
NP_001273344
NP_032026

Location (UCSC)Chr 5: 108.75 – 109.2 MbChr 17: 63.9 – 64.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[5]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[5]

Interactions[edit]

FER (gene) has been shown to interact with TMF1[6] and Cortactin.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151422 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000127 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)".
  6. ^ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. NETHERLANDS. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951.
  7. ^ Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. UNITED STATES. 273 (36): 23542–8. doi:10.1074/jbc.273.36.23542. ISSN 0021-9258. PMID 9722593.

Further reading[edit]