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Protein FGF10 PDB 1nun.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases FGF10
External IDs MGI: 1099809 HomoloGene: 3284 GeneCards: 2255
Genetically Related Diseases
Disease Name References
prostate cancer
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 44.3 – 44.39 Mb Chr 13: 118.67 – 118.79 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[1][2]


The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.[2]


  1. ^ Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324. 
  2. ^ a b "Entrez Gene: FGF10 fibroblast growth factor 10". 

Further reading[edit]

  • Igarashi M, Finch PW, Aaronson SA (May 1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)". The Journal of Biological Chemistry 273 (21): 13230–5. doi:10.1074/jbc.273.21.13230. PMID 9582367. 
  • Sekine K, Ohuchi H, Fujiwara M, Yamasaki M, Yoshizawa T, Sato T, Yagishita N, Matsui D, Koga Y, Itoh N, Kato S (January 1999). "Fgf10 is essential for limb and lung formation". Nature Genetics 21 (1): 138–41. doi:10.1038/5096. PMID 9916808. 
  • Jimenez PA, Rampy MA (February 1999). "Keratinocyte growth factor-2 accelerates wound healing in incisional wounds". The Journal of Surgical Research 81 (2): 238–42. doi:10.1006/jsre.1998.5501. PMID 9927546. 
  • Ropiquet F, Giri D, Kwabi-Addo B, Schmidt K, Ittmann M (September 2000). "FGF-10 is expressed at low levels in the human prostate". The Prostate 44 (4): 334–8. doi:10.1002/1097-0045(20000901)44:4<334::AID-PROS11>3.0.CO;2-G. PMID 10951499. 
  • Marchese C, Felici A, Visco V, Lucania G, Igarashi M, Picardo M, Frati L, Torrisi MR (April 2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes". The Journal of Investigative Dermatology 116 (4): 623–8. doi:10.1046/j.0022-202x.2001.01280.x. PMID 11286634. 
  • Bagai S, Rubio E, Cheng JF, Sweet R, Thomas R, Fuchs E, Grady R, Mitchell M, Bassuk JA (June 2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells". The Journal of Biological Chemistry 277 (26): 23828–37. doi:10.1074/jbc.M201658200. PMID 11923311. 
  • Yeh BK, Igarashi M, Eliseenkova AV, Plotnikov AN, Sher I, Ron D, Aaronson SA, Mohammadi M (March 2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors". Proceedings of the National Academy of Sciences of the United States of America 100 (5): 2266–71. doi:10.1073/pnas.0436500100. PMC 151329. PMID 12591959. 
  • Upadhyay D, Lecuona E, Comellas A, Kamp DW, Sznajder JI (June 2003). "Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway". FEBS Letters 545 (2-3): 173–6. doi:10.1016/S0014-5793(03)00527-1. PMID 12804770. 
  • Izvolsky KI, Zhong L, Wei L, Yu Q, Nugent MA, Cardoso WV (October 2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching". American Journal of Physiology. Lung Cellular and Molecular Physiology 285 (4): L838–46. doi:10.1152/ajplung.00081.2003. PMID 12818887. 
  • Tomlinson DC, Grindley JC, Thomson AA (April 2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements". Endocrinology 145 (4): 1988–95. doi:10.1210/en.2003-0842. PMID 14726452. 
  • Upadhyay D, Bundesmann M, Panduri V, Correa-Meyer E, Kamp DW (July 2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair". American Journal of Respiratory Cell and Molecular Biology 31 (1): 107–13. doi:10.1165/rcmb.2003-0064OC. PMID 14975937. 
  • Theodorou V, Boer M, Weigelt B, Jonkers J, van der Valk M, Hilkens J (August 2004). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas". Oncogene 23 (36): 6047–55. doi:10.1038/sj.onc.1207816. PMID 15208658. 
  • Ibrahimi OA, Yeh BK, Eliseenkova AV, Zhang F, Olsen SK, Igarashi M, Aaronson SA, Linhardt RJ, Mohammadi M (January 2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization". Molecular and Cellular Biology 25 (2): 671–84. doi:10.1128/MCB.25.2.671-684.2005. PMC 543411. PMID 15632068. 
  • Entesarian M, Matsson H, Klar J, Bergendal B, Olson L, Arakaki R, Hayashi Y, Ohuchi H, Falahat B, Bolstad AI, Jonsson R, Wahren-Herlenius M, Dahl N (February 2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands". Nature Genetics 37 (2): 125–7. doi:10.1038/ng1507. PMID 15654336. 
  • Kovacs D, Falchi M, Cardinali G, Raffa S, Carducci M, Cota C, Amantea A, Torrisi MR, Picardo M (February 2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis". Experimental Dermatology 14 (2): 130–7. doi:10.1111/j.0906-6705.2005.00261.x. PMID 15679583. 
  • Ye F, Duvillié B, Scharfmann R (February 2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells". Diabetologia 48 (2): 277–81. doi:10.1007/s00125-004-1638-6. PMID 15690149. 
  • Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S (August 2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171. 

External links[edit]