FGF10

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
FGF10
Protein FGF10 PDB 1nun.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFGF10, fibroblast growth factor 10
External IDsOMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for FGF10
Genomic location for FGF10
Band5p12Start44,300,247 bp[1]
End44,389,706 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004465

NM_008002

RefSeq (protein)

NP_004456

NP_032028

Location (UCSC)Chr 5: 44.3 – 44.39 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[4][5]

Function[edit]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development. FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands. During the limb development Tbx4/Tbx5 stimulate the production of FGF10 in the lateral plate mesoderm where it will create an epithelial-mesenchymal FGF signal with FGF8. This positive feedback loop will increase the amount of mesenchyme resulting in a bulge. Afterwards, FGF10 will induce the formation of apical ectodermal ridge (AER) where the foot and hands will be formed. Lung development uses the same epithelial-mesenchymal signaling from FGF10 in the foregut mesenchyme with FGFR2 in the foregut epithelium. FGF10 signaling is required for epithelial branching. Therefore, all branching morphogen organs such as the lungs, skin, ear and salivary glands required the constant expression of FGF10. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.[5]

Clinical significance[edit]

Nonsense mutations may also occur with the absence of FGF10 such as LADD and ALSG syndrome. Nevertheless complications may arise from FGF10 signaling such as pancreatic and breast cancer. Although this gene is also implicated to be a primary factor in the process of wound healing.[5]

Animal studies[edit]

FGF10 knockout mice die right after birth. The mice showed no developing organs such as lungs, salivary glands, kidney or definitive limbs once autopsied. Studies of the mouse homolog suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070193 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry. 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.
  5. ^ a b c "Entrez Gene: FGF10 fibroblast growth factor 10".
  6. ^ Itoh N, Ohta H (2014). "Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine". Current Molecular Medicine. 14 (4): 504–9. doi:10.2174/1566524014666140414204829. PMID 24730525.

Further reading[edit]

External links[edit]