FGF14

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FGF14
Identifiers
AliasesFGF14, FGF-14, FHF-4, FHF4, SCA27, fibroblast growth factor 14
External IDsMGI: 109189 HomoloGene: 3037 GeneCards: FGF14
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for FGF14
Genomic location for FGF14
Band13q33.1Start101,710,804 bp[1]
End102,402,457 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010201
NM_207667

RefSeq (protein)

NP_034331
NP_997550

Location (UCSC)Chr 13: 101.71 – 102.4 MbChr 14: 123.98 – 124.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 14 is a protein that in humans is encoded by the FGF14 gene.[5][6][7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102466 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025551 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  6. ^ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis. 26 (1): 14–26. doi:10.1016/j.nbd.2006.11.014. PMC 2267915. PMID 17236779.
  7. ^ a b "Entrez Gene: FGF14 fibroblast growth factor 14".

Further reading[edit]