FGF7

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FGF7
Protein FGF7 PDB 1qqk.png
Identifiers
Aliases FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs MGI: 95521 HomoloGene: 7316 GeneCards: FGF7
RNA expression pattern
PBB GE FGF7 205782 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002009

NM_008008

RefSeq (protein)

NP_002000

NP_032034.1
NP_032034

Location (UCSC) Chr 15: 49.42 – 49.49 Mb Chr 2: 126.03 – 126.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.[5]

Interactions[edit]

FGF7 has been shown to interact with Perlecan.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227. 
  4. ^ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111Freely accessible. PMID 1409637. 
  5. ^ a b "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)". 
  6. ^ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276. 

Further reading[edit]