FGG

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This article is about the gene. For the sports organization, see Federation of Gay Games. For the Susumu Hirasawa song, see The Ghost in Science.
FGG
Protein FGG PDB 1fib.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FGG
External IDs MGI: 95526 HomoloGene: 429 GeneCards: 2266
RNA expression pattern
PBB GE FGG 219612 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021870
NM_000509

NM_133862
NM_001317105

RefSeq (protein)

NP_000500.2
NP_068656.2

NP_598623.1

Location (UCSC) Chr 4: 154.6 – 154.61 Mb Chr 3: 83.01 – 83.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4.

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.[1] Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased levels of γA/γ' fibrinogen have been associated with CAD and DVT respectively.

References[edit]

Further reading[edit]