FKBP2

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FKBP2
Protein FKBP2 PDB 2pbc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FKBP2, FKBP-13, PPIase, FK506 binding protein 2
External IDs MGI: 95542 HomoloGene: 40604 GeneCards: FKBP2
RNA expression pattern
PBB GE FKBP2 203391 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135208
NM_004470
NM_057092

NM_001166368
NM_008020

RefSeq (protein)

NP_001128680
NP_004461
NP_476433

NP_001159840.1
NP_032046.1
NP_001159840
NP_032046

Location (UCSC) Chr 11: 64.24 – 64.24 Mb Chr 19: 6.98 – 6.98 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[4]

Interactions[edit]

FKBP2 has been shown to interact with ARFGEF1[5] and EPB41L2.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ (Sep 1991). "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6677–81. doi:10.1073/pnas.88.15.6677. PMC 52151Freely accessible. PMID 1713687. 
  4. ^ a b "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa". 
  5. ^ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339Freely accessible. PMID 12606707. 
  6. ^ Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (Apr 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". J. Cell Biol. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710Freely accessible. PMID 9531554. 

Further reading[edit]