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Protein FKBP3 PDB 1pbk.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases FKBP3, FKBP-25, FKBP-3, FKBP25, PPIase, FK506 binding protein 3
External IDs MGI: 1353460 HomoloGene: 1525 GeneCards: FKBP3
RNA expression pattern
PBB GE FKBP3 218003 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 14: 45.12 – 45.14 Mb Chr 12: 65.06 – 65.07 Mb
PubMed search [1] [2]
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FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.[3][4][5]


The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[5]


FKBP3 has been shown to interact with YY1,[6] HDAC1,[6] Histone deacetylase 2[6] and Mdm2.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hung DT, Schreiber SL (Jun 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 184 (2): 733–8. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240. 
  4. ^ Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J. 6 (7): 2482–6. PMID 1532945. 
  5. ^ a b "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa". 
  6. ^ a b c Yang WM, Yao YL, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595Freely accessible. PMID 11532945. 
  7. ^ Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D (Feb 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. 

Further reading[edit]