FKBP52

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FKBP4
Protein FKBP4 PDB 1n1a.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFKBP4, FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52, FK506 binding protein 4
External IDsOMIM: 600611 MGI: 95543 HomoloGene: 36085 GeneCards: FKBP4
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for FKBP4
Genomic location for FKBP4
Band12p13.33Start2,794,953 bp[1]
End2,805,423 bp[1]
RNA expression pattern
PBB GE FKBP4 200894 s at fs.png

PBB GE FKBP4 200895 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002014

NM_010219

RefSeq (protein)

NP_002005

NP_034349

Location (UCSC)Chr 12: 2.79 – 2.81 MbChr 6: 128.43 – 128.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.[6]

Structure[edit]

This protein contains TPR repeats and has a PPlase domain.

Clinical significance[edit]

Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.[7]

Interactions[edit]

FKBP52 has been shown to interact with GLMN.[8][9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004478 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030357 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M (November 1992). "Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes". Proceedings of the National Academy of Sciences of the United States of America. 89 (22): 10974–8. doi:10.1073/pnas.89.22.10974. PMC 50465Freely accessible. PMID 1279700. 
  6. ^ a b "Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa". 
  7. ^ Blair LJ, Baker JD, Sabbagh JJ, Dickey CA (April 2015). "The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease". Journal of Neurochemistry. 133 (1): 1–13. doi:10.1111/jnc.13033. PMC 4361273Freely accessible. PMID 25628064. 
  8. ^ Chambraud B, Radanyi C, Camonis JH, Shazand K, Rajkowski K, Baulieu EE (December 1996). "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin". The Journal of Biological Chemistry. 271 (51): 32923–9. doi:10.1074/jbc.271.51.32923. PMID 8955134. 
  9. ^ Neye H (March 2001). "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regulatory Peptides. 97 (2-3): 147–52. doi:10.1016/S0167-0115(00)00206-8. PMID 11164950. 

Further reading[edit]

External links[edit]