FKBP5

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FKBP5
Protein FKBP5 PDB 1kt0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5
External IDs MGI: 104670 HomoloGene: 3038 GeneCards: 2289
RNA expression pattern
PBB GE FKBP5 204560 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004117
NM_001145775
NM_001145776
NM_001145777

NM_010220

RefSeq (protein)

NP_001139247.1
NP_001139248.1
NP_001139249.1
NP_004108.1

NP_034350.1

Location (UCSC) Chr 6: 35.57 – 35.73 Mb Chr 17: 28.4 – 28.52 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.[3]

Function[edit]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.

Clinical significance[edit]

Genetic studies have identified a role for FKBP5 in posttraumatic stress disorder, depression and anxiety.[4] For example, single nucleotide polymorphisms (SNPs) in FKBP5 have been found to interact with childhood trauma to predict severity of adult posttraumatic stress disorder (PTSD).[5] These findings suggest that individuals with these SNPs who are abused as children are more susceptible to PTSD as adults. FKBP5 has also been found to be less expressed in individuals with current PTSD.[6] The FKBP5 gene has been found to have multiple polyadenylation sites[3] and is statistically associated with a higher rate of depressive disorders.[7]

Interactions[edit]

FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.[8]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: FKBP5 FK506 binding protein 5". 
  4. ^ http://www.psychologytoday.com/blog/mouse-man/200811/gene-anxiety-depression-and-posttraumatic-stress-disorder-fkbp5
  5. ^ Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim CM, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ (2008). "Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults". JAMA. 299 (11): 1291–305. doi:10.1001/jama.299.11.1291. PMC 2441757free to read. PMID 18349090. 
  6. ^ Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Holsboer F, Buxbaum JD (2009). "Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks". Biol. Psychiatry. 66 (7): 708–11. doi:10.1016/j.biopsych.2009.02.034. PMID 19393990. 
  7. ^ Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Mueller JC, Lõhmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B (December 2004). "Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment". Nat. Genet. 36 (12): 1319–25. doi:10.1038/ng1479. PMID 15565110. 
  8. ^ Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF (Feb 1997). "Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor". Mol. Cell. Biol. 17 (2): 594–603. PMC 231784free to read. PMID 9001212. 

Further reading[edit]