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Flotillin 1
Symbol FLOT1
External IDs OMIM606998 MGI1100500 HomoloGene31337 GeneCards: FLOT1 Gene
RNA expression pattern
PBB GE FLOT1 208748 s at tn.png
PBB GE FLOT1 208749 x at tn.png
PBB GE FLOT1 210142 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10211 14251
Ensembl ENSG00000137312 ENSMUSG00000059714
UniProt O75955 O08917
RefSeq (mRNA) NM_005803 NM_008027
RefSeq (protein) NP_005794 NP_032053
Location (UCSC) Chr 6:
30.73 – 30.74 Mb
Chr 17:
35.82 – 35.83 Mb
PubMed search [1] [2]

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[2] The function of flotillin 1 has not been determined.[1]


FLOT1 has been shown to interact with SORBS1.[3][4][5]


  1. ^ a b "Entrez Gene: FLOT1 flotillin 1". 
  2. ^ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235. 
  3. ^ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. 
  4. ^ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport". Nature 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060. 
  5. ^ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476. 

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