FLOT1

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FLOT1
Identifiers
Aliases FLOT1
External IDs MGI: 1100500 HomoloGene: 31337 GeneCards: 10211
RNA expression pattern
PBB GE FLOT1 208748 s at tn.png

PBB GE FLOT1 208749 x at tn.png

PBB GE FLOT1 210142 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005803
NM_001318875

NM_008027

RefSeq (protein)

NP_005794.1
NP_001305804.1

NP_032053.1

Location (UCSC) Chr 6: 30.73 – 30.74 Mb Chr 17: 35.82 – 35.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[3]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[4] The function of flotillin 1 has not been determined.[3]

Interactions[edit]

FLOT1 has been shown to interact with SORBS1.[5][6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: FLOT1 flotillin 1". 
  4. ^ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235. 
  5. ^ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. 
  6. ^ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport". Nature. 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060. 
  7. ^ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMC 55379free to read. PMID 11481476. 

Further reading[edit]

External links[edit]