FMO4

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FMO4
Identifiers
Aliases FMO4, FMO2, flavin containing monooxygenase 4
External IDs MGI: 2429497 HomoloGene: 68219 GeneCards: 2329
RNA expression pattern
PBB GE FMO4 206263 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002022

NM_144878

RefSeq (protein)

NP_002013.1

NP_659127.1

Location (UCSC) Chr 1: 171.31 – 171.34 Mb Chr 1: 162.79 – 162.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme that in humans is encoded by the FMO4 gene.[3][4]

Function[edit]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J, Phillips IR (Mar 1994). "A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities". Arch Biochem Biophys. 308 (1): 254–7. doi:10.1006/abbi.1994.1035. PMID 8311461. 
  4. ^ a b "Entrez Gene: FMO4 flavin containing monooxygenase 4". 

Further reading[edit]