FOSL1

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FOSL1
Identifiers
Aliases FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 trancription factor subunit
External IDs MGI: 107179 HomoloGene: 3967 GeneCards: 8061
RNA expression pattern
PBB GE FOSL1 204420 at tn.png

PBB GE FOSL1 213250 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300844
NM_001300855
NM_001300856
NM_001300857
NM_005438

NM_010235

RefSeq (protein)

NP_001287773.1
NP_001287784.1
NP_001287785.1
NP_001287786.1
NP_005429.1

NP_034365.1

Location (UCSC) Chr 11: 65.89 – 65.9 Mb Chr 19: 5.45 – 5.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[3][4]

Function[edit]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[4]

Interactions[edit]

FOSL1 has been shown to interact with USF1 (human gene)[5] and C-jun.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490. 
  4. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  5. ^ a b Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.