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FOS-like antigen 1
Symbols FOSL1 ; FRA; FRA1; fra-1
External IDs OMIM136515 MGI107179 HomoloGene3967 GeneCards: FOSL1 Gene
RNA expression pattern
PBB GE FOSL1 204420 at tn.png
PBB GE FOSL1 213250 at tn.png
More reference expression data
Species Human Mouse
Entrez 8061 14283
Ensembl ENSG00000175592 ENSMUSG00000024912
UniProt P15407 P48755
RefSeq (mRNA) NM_001300844 NM_010235
RefSeq (protein) NP_001287773 NP_034365
Location (UCSC) Chr 11:
65.89 – 65.9 Mb
Chr 19:
5.45 – 5.46 Mb
PubMed search [1] [2]

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[1][2]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]


FOSL1 has been shown to interact with USF1 (human gene)[3] and C-jun.[3]

See also[edit]


  1. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Apr 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene 5 (3): 249–55. PMID 2107490. 
  2. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  3. ^ a b Pognonec, P; Boulukos K E; Aperlo C; Fujimoto M; Ariga H; Nomoto A; Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.