FOXA2

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FOXA2
Identifiers
Aliases FOXA2, HNF3B, TCF3B, forkhead box A2
External IDs MGI: 1347476 HomoloGene: 7762 GeneCards: 3170
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021784
NM_153675

NM_001291065
NM_001291067
NM_010446

RefSeq (protein)

NP_068556.2
NP_710141.1

NP_001277994.1
NP_034576.2

Location (UCSC) Chr 20: 22.58 – 22.59 Mb Chr 2: 148.04 – 148.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene.[1][2][3]

Function[edit]

Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.[1]

References[edit]

  1. ^ a b "Entrez Gene: forkhead box A2". 
  2. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385. 
  3. ^ Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70. doi:10.1074/jbc.M111037200. PMID 11875061. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.