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Forkhead box A2
Symbols FOXA2 ; HNF3B; TCF3B
External IDs OMIM600288 MGI1347476 HomoloGene7762 GeneCards: FOXA2 Gene
Species Human Mouse
Entrez 3170 15376
Ensembl ENSG00000125798 ENSMUSG00000037025
UniProt Q9Y261 P35583
RefSeq (mRNA) NM_021784 NM_001291065
RefSeq (protein) NP_068556 NP_001277994
Location (UCSC) Chr 20:
22.58 – 22.59 Mb
Chr 2:
148.04 – 148.05 Mb
PubMed search [1] [2]

Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene.[1][2][3]


Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.[1]


  1. ^ a b "Entrez Gene: forkhead box A2". 
  2. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385. 
  3. ^ Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70. doi:10.1074/jbc.M111037200. PMID 11875061. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.