FOXA3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FOXA3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FOXA3, FKHH3, HNF3G, TCF3G, forkhead box A3
External IDs MGI: 1347477 HomoloGene: 3308 GeneCards: FOXA3
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FOXA3
Genomic location for FOXA3
Band 19q13.32 Start 45,863,989 bp[1]
End 45,873,797 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004497

NM_008260

RefSeq (protein)

NP_004488

NP_032286

Location (UCSC) Chr 19: 45.86 – 45.87 Mb Chr 19: 19.01 – 19.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.[5][6]

Function[edit]

HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170608 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040891 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: forkhead box A3". 
  6. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. PMID 9119385. doi:10.1006/geno.1996.4477. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.