FOXA3

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FOXA3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FOXA3, FKHH3, HNF3G, TCF3G, forkhead box A3
External IDs MGI: 1347477 HomoloGene: 3308 GeneCards: 3171
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004497

NM_008260

RefSeq (protein)

NP_004488.2

NP_032286.1

Location (UCSC) Chr 19: 45.86 – 45.87 Mb Chr 7: 19.01 – 19.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.[3][4]

Function[edit]

HNF-3G is a member of the forkheadclass of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: forkhead box A3". 
  4. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.