FOXF1

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Forkhead box F1
Identifiers
Symbols FOXF1 ; ACDMPV; FKHL5; FREAC1
External IDs OMIM601089 MGI1347470 HomoloGene1114 GeneCards: FOXF1 Gene
RNA expression pattern
PBB GE FOXF1 205935 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2294 15227
Ensembl ENSG00000103241 ENSMUSG00000042812
UniProt Q12946 Q61080
RefSeq (mRNA) NM_001451 NM_010426
RefSeq (protein) NP_001442 NP_034556
Location (UCSC) Chr 16:
86.51 – 86.52 Mb
Chr 8:
121.08 – 121.09 Mb
PubMed search [1] [2]

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.[1][2][3]

Function[edit]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.[3]

References[edit]

  1. ^ Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632. 
  2. ^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal 13 (20): 5002–12. PMC 395442. PMID 7957066. 
  3. ^ a b "Entrez Gene: FOXF1 forkhead box F1". 

Further reading[edit]

  • Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731. 
  • Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802. 
  • Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567. 
  • Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171. 
  • Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649. 
  • Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323. 

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.