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Forkhead box F1
External IDs OMIM601089 MGI1347470 HomoloGene1114 GeneCards: FOXF1 Gene
RNA expression pattern
PBB GE FOXF1 205935 at tn.png
More reference expression data
Species Human Mouse
Entrez 2294 15227
Ensembl ENSG00000103241 ENSMUSG00000042812
UniProt Q12946 Q61080
RefSeq (mRNA) NM_001451 NM_010426
RefSeq (protein) NP_001442 NP_034556
Location (UCSC) Chr 16:
86.51 – 86.52 Mb
Chr 8:
121.08 – 121.09 Mb
PubMed search [1] [2]

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.[1][2][3]


This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.[3]


  1. ^ Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632. 
  2. ^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal 13 (20): 5002–12. PMC 395442. PMID 7957066. 
  3. ^ a b "Entrez Gene: FOXF1 forkhead box F1". 

Further reading[edit]

  • Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731. 
  • Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802. 
  • Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567. 
  • Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171. 
  • Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649. 
  • Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.