FOXH1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FOXH1
Identifiers
Aliases FOXH1, FAST-1, FAST1, forkhead box H1
External IDs MGI: 1347465 HomoloGene: 2914 GeneCards: 8928
RNA expression pattern
PBB GE FOXH1 207644 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003923

NM_007989

RefSeq (protein)

NP_003914.1

NP_032015.1

Location (UCSC) Chr 8: 144.47 – 144.48 Mb Chr 15: 76.67 – 76.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

Function[edit]

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

Interactions[edit]

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

See also[edit]

References[edit]

  1. ^ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198. 
  2. ^ a b "Entrez Gene: FOXH1 forkhead box H1". 
  3. ^ Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. 
  4. ^ Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. 
  5. ^ Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566. 
  6. ^ Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648. 
  7. ^ Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097. 
  8. ^ Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.