FOXJ1

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Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene.[1] It has been shown that this gene is a transcription factor involved in ciliogenesis.[2]

FOXJ1
Identifiers
Aliases FOXJ1, FKHL13, HFH-4, HFH4, forkhead box J1
External IDs MGI: 1347474 HomoloGene: 1117 GeneCards: 2302
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001454

NM_008240

RefSeq (protein)

NP_001445.2

NP_032266.3

Location (UCSC) Chr 17: 76.14 – 76.14 Mb Chr 11: 116.33 – 116.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function[edit]

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.[1]

Clinical significance[edit]

Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[1]

References[edit]

  1. ^ a b c "Entrez Gene: forkhead box J1". 
  2. ^ Yu X, Ng CP, Habacher H, Roy S (December 2008). "Foxj1 transcription factors are master regulators of the motile ciliogenic program". Nat. Genet. 40 (12): 1445–53. doi:10.1038/ng.263. PMID 19011630. 
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.