FOXK1

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FOXK1
Protein FOXK1 PDB 2a3s.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFOXK1, FOXK1L, forkhead box K1
External IDsOMIM: 616302 MGI: 1347488 HomoloGene: 82414 GeneCards: FOXK1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for FOXK1
Genomic location for FOXK1
Band7p22.1Start4,682,295 bp[1]
End4,771,442 bp[1]
RNA expression pattern
PBB GE FOXK1 gnf1h04694 s at fs.png

PBB GE FOXK1 gnf1h04695 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001037165

NM_010812
NM_199068

RefSeq (protein)

NP_001032242

NP_951031

Location (UCSC)Chr 7: 4.68 – 4.77 MbChr 5: 142.4 – 142.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.[5][6]


During starvation, in type 2 diabetes, in rapidly dividing cells during embryogenesis, in tumors (Warburg effect) and during T cell proliferation, aerobic glycolysis is induced to produce the building block to sustain growth. FOXK1 is one of the transcription factors managing the passage from the normal cellular respiration (complete glucose oxidation) to generating ATP and intermediaries for many other biochemical pathways.[7]

FOXK1 and its closely relate sibling FOXK2 induce aerobic glycolysis by upregulating the enzymatic machinery required for this (for example, hexokinase-2, phosphofructokinase, pyruvate kinase, and lactate dehydrogenase), while at the same time suppressing further oxidation of pyruvate in the mitochondria by increasing the activity of pyruvate dehydrogenase kinases 1 and 4. Together with suppression of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 this leads to increased phosphorylation of the E1α regulatory subunit of the pyruvate dehydrogenase complex, which in turn inhibits further oxidation of pyruvate in the mitochondria—instead, pyruvate is reduced to lactate. Suppression of FOXK1 and FOXK2 induce the opposite phenotype. Both in vitro and in vivo experiments, including studies of primary human cells, show how FOXK1 and/or FOXK2 are likely to act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164916 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056493 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (Jun 2004). "Identification and characterization of human FOXK1 gene in silico". Int J Mol Med. 14 (1): 127–32. doi:10.3892/ijmm.14.1.127. PMID 15202027.
  6. ^ "Entrez Gene: FOXK1 forkhead box K1".
  7. ^ a b Sukonina, Valentina; Ma, Haixia; Zhang, Wei; Bartesaghi, Stefano; Subhash, Santhilal; Heglind, Mikael; Foyn, Håvard; Betz, Matthias J.; Nilsson, Daniel (Jan 2019). "FOXK1 and FOXK2 regulate aerobic glycolysis". Nature. 566 (7743): 279–283. doi:10.1038/s41586-019-0900-5. ISSN 1476-4687. PMID 30700909.

Further reading[edit]