FRS3

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FRS3
Protein FRS3 PDB 2KUP.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3
External IDsMGI: 2135965 HomoloGene: 4845 GeneCards: FRS3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FRS3
Genomic location for FRS3
Band6p21.1Start41,770,176 bp[1]
End41,786,542 bp[1]
RNA expression pattern
PBB GE FRS3 219907 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006653

NM_144939

RefSeq (protein)

NP_006644

NP_659188

Location (UCSC)Chr 6: 41.77 – 41.79 MbChr 17: 47.69 – 47.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.[5][6][7]

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137218 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023266 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Wang JK, Xu H, Li HC, Goldfarb M (Oct 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721–9. PMID 8761293.
  6. ^ Xu H, Lee KW, Goldfarb M (Aug 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem. 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748.
  7. ^ a b "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3".

Further reading[edit]