FSCN1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FSCN1
Protein FSCN1 PDB 1dfc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDs MGI: 1352745 HomoloGene: 48164 GeneCards: FSCN1
RNA expression pattern
PBB GE FSCN1 210933 s at fs.png

PBB GE FSCN1 201564 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003088

NM_007984

RefSeq (protein)

NP_003079

NP_032010.2
NP_032010

Location (UCSC) Chr 7: 5.59 – 5.61 Mb Chr 5: 142.96 – 142.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fascin is a protein that in humans is encoded by the FSCN1 gene.[3][4][5]

Interactions[edit]

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor[6] and PKC alpha.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206. 
  4. ^ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262. 
  5. ^ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)". 
  6. ^ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. 
  7. ^ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775Freely accessible. PMID 14532112. 

Further reading[edit]