FSTL1 protein seems to have a cardioprotective role. FSTL1 attenuated hypertrophy following pressure overload and prevented myocardial ischemia/reperfusion injury in a mouse or pig model of ischemia/reperfusion. Muscle-derived Fstl1 modulates vascular remodelling in response to injury.
FSTL1 has been shown to have a pronounced ability as a possible therapeutic to stimulate regeneration following myocardial infarction. Treating experimental animals (mouse and pig) with FSTL1 after myocardial infarction progressively restored heart function, at least in part by stimulating replication of normally non-dividing heart muscle cells
^Zwijsen A, Blockx H, Van Arnhem W, Willems J, Fransen L, Devos K, Raymackers J, Van de Voorde A, Slegers H (Nov 1994). "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue". European Journal of Biochemistry / FEBS. 225 (3): 937–46. doi:10.1111/j.1432-1033.1994.0937b.x. PMID7957230.
^Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C (Oct 2009). "The expression pattern of Follistatin-like 1 in mouse central nervous system development". Gene Expression Patterns. 9 (7): 532–40. doi:10.1016/j.gep.2009.07.001. PMID19595790.
^Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R (Jul 2015). "Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells". Annals of the Rheumatic Diseases. 74 (7): 1467–73. doi:10.1136/annrheumdis-2013-204822. PMID24641944.
Vertegaal AC, Kuiperij HB, van Laar T, Scharnhorst V, van der Eb AJ, Zantema A (Dec 2000). "cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells". FEBS Letters. 487 (2): 151–5. doi:10.1016/S0014-5793(00)02339-5. PMID11150499.
Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F (Aug 2004). "Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma". European Journal of Endocrinology. 151 (2): 251–7. doi:10.1530/eje.0.1510251. PMID15296481.
Ehara Y, Sakurai D, Tsuchiya N, Nakano K, Tanaka Y, Yamaguchi A, Tokunaga K (2005). "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility". Clinical and Experimental Rheumatology. 22 (6): 707–12. PMID15638044.
Liu S, Wang L, Wang W, Lin J, Han J, Sun H, Guo H, Sun R, Wu Q (Apr 2006). "TSC-36/FRP inhibits vascular smooth muscle cell proliferation and migration". Experimental and Molecular Pathology. 80 (2): 132–40. doi:10.1016/j.yexmp.2005.07.005. PMID16256108.