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Legal status
Legal status
CAS Number
PubChem CID
Chemical and physical data
Molar mass403.501 g·mol−1
3D model (JSmol)

FUB-APINACA (also known as AFUBINACA and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1] It is an analog of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.


FUB-APINACA acts as a full agonist with a binding affinity of 1.06 nM at CB1 and 0.174 nM at CB2 cannabinoid receptors.[2]

Legal status[edit]

In the United States, FUB-APINACA became a Schedule I Controlled Substance in 2019.[3] Previously, it was illegal only in Alabama (listed as FUB-AKB48).[4]

Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.[5]

See also[edit]


  1. ^ "FUB-AKB48". Cayman Chemical. Retrieved 23 July 2015.
  2. ^ Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE (2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. PMC 4929166. PMID 27429655.
  3. ^ "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register. 2019-04-16.
  4. ^ Alabama Senate Bill SB 333: Controlled Substances
  5. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. Retrieved 23 July 2015.