FUT2

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FUT2
Identifiers
Aliases FUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDs MGI: 109374 HomoloGene: 10325 GeneCards: 2524
Genetically Related Diseases
Disease Name References
obesity
Crohn's disease
RNA expression pattern
PBB GE FUT2 208505 s at tn.png

PBB GE FUT2 210608 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (protein)

NP_000502.4
NP_001091107.1

NP_001258922.1
NP_061364.2

Location (UCSC) Chr 19: 48.7 – 48.71 Mb Chr 7: 45.65 – 45.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[1][2] It affects the Lewis blood group.

Approximately 20% of Caucasians are non-secretors due to the G428A and C571T nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.


References[edit]

  1. ^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. 
  2. ^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)". 

Further reading[edit]