FUT8

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FUT8
Protein FUT8 PDB 2de0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FUT8, fucosyltransferase 8
External IDs MGI: 1858901 HomoloGene: 9650 GeneCards: FUT8
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for FUT8
Genomic location for FUT8
Band 14q23.3 Start 65,410,592 bp[1]
End 65,744,121 bp[1]
RNA expression pattern
PBB GE FUT8 203988 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004480
NM_178154
NM_178155
NM_178156
NM_178157

NM_001252614
NM_001252615
NM_001252616
NM_016893

RefSeq (protein)

NP_004471
NP_835368
NP_835369

NP_001239543
NP_001239544
NP_001239545
NP_058589

Location (UCSC) Chr 14: 65.41 – 65.74 Mb Chr 14: 77.24 – 77.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.[5][6]

This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000033170 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021065 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Costache M, Apoil PA, Cailleau A, Elmgren A, Larson G, Henry S, Blancher A, Iordachescu D, Oriol R, Mollicone R (Dec 1997). "Evolution of fucosyltransferase genes in vertebrates". J Biol Chem. 272 (47): 29721–8. PMID 9368041. doi:10.1074/jbc.272.47.29721. 
  6. ^ a b "Entrez Gene: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)". 

Further reading[edit]