FXR1

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FXR1
Protein FXR1 PDB 2cpq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FXR1, FXR1P, FMR1 autosomal homolog 1
External IDs MGI: 104860 HomoloGene: 3573 GeneCards: FXR1
RNA expression pattern
PBB GE FXR1 201637 s at fs.png

PBB GE FXR1 201636 at fs.png

PBB GE FXR1 201635 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001013438
NM_001013439
NM_005087

NM_001113188
NM_001113189
NM_008053

RefSeq (protein)

NP_001013456
NP_001013457
NP_005078

Location (UCSC) Chr 3: 180.87 – 180.98 Mb Chr 3: 34.02 – 34.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.[3][4][5]

The protein encoded by this gene is an RNA binding protein that interacts with the functionally similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.[5]

Interactions[edit]

FXR1 has been shown to interact with FXR2,[6][7] FMR1 [6][7] and CYFIP2.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Siomi MC, Siomi H, Sauer WH, Srinivasan S, Nussbaum RL, Dreyfuss G (July 1995). "FXR1, an autosomal homolog of the fragile X mental retardation gene". EMBO J. 14 (11): 2401–8. PMC 398353Freely accessible. PMID 7781595. 
  4. ^ Bolivar J, Guelman S, Iglesias C, Ortiz M, Valdivia MM (August 1998). "The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis". J Biol Chem. 273 (27): 17122–7. doi:10.1074/jbc.273.27.17122. PMID 9642279. 
  5. ^ a b "Entrez Gene: FXR1 fragile X mental retardation, autosomal homolog 1". 
  6. ^ a b Siomi, M C; Zhang Y; Siomi H; Dreyfuss G (July 1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them". Mol. Cell. Biol. UNITED STATES. 16 (7): 3825–32. doi:10.1128/mcb.16.7.3825. ISSN 0270-7306. PMC 231379Freely accessible. PMID 8668200. 
  7. ^ a b Zhang, Y; O'Connor J P; Siomi M C; Srinivasan S; Dutra A; Nussbaum R L; Dreyfuss G (November 1995). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2". EMBO J. ENGLAND. 14 (21): 5358–66. ISSN 0261-4189. PMC 394645Freely accessible. PMID 7489725. 
  8. ^ Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523Freely accessible. PMID 11438699. 

Further reading[edit]