FZD1

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Frizzled class receptor 1
Identifiers
Symbols FZD1 ; DKFZp564G072; FLJ95923
External IDs OMIM603408 MGI1196625 HomoloGene20750 IUPHAR: 229 GeneCards: FZD1 Gene
RNA expression pattern
PBB GE FZD1 204451 at tn.png
PBB GE FZD1 204452 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8321 14362
Ensembl ENSG00000157240 ENSMUSG00000044674
UniProt Q9UP38 O70421
RefSeq (mRNA) NM_003505 NM_021457
RefSeq (protein) NP_003496 NP_067432
Location (UCSC) Chr 7:
90.89 – 90.9 Mb
Chr 5:
4.75 – 4.76 Mb
PubMed search [1] [2]

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.[1][2]

Function[edit]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]

See also[edit]

References[edit]

  1. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  2. ^ a b "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)". 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.