FZD1

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FZD1
Identifiers
Aliases FZD1
External IDs MGI: 1196625 HomoloGene: 20750 GeneCards: 8321
RNA expression pattern
PBB GE FZD1 204451 at tn.png

PBB GE FZD1 204452 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003505

NM_021457

RefSeq (protein)

NP_003496.1

NP_067432.2

Location (UCSC) Chr 7: 91.26 – 91.27 Mb Chr 5: 4.75 – 4.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.[1][2]

Function[edit]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]

See also[edit]

References[edit]

  1. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  2. ^ a b "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)". 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.