This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.
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Kumar S, Connor JR, Dodds RA; et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil.9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID11597177.
Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". Int. J. Mol. Med.9 (2): 107–12. doi:10.3892/ijmm.9.2.107. PMID11786918.
Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet.25 (2): 81–90. doi:10.1080/13816810490514270. PMID15370539.