FZD10

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FZD10
Identifiers
Aliases FZD10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10
External IDs MGI: 2136761 HomoloGene: 21411 GeneCards: FZD10
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for FZD10
Genomic location for FZD10
Band 12q24.33 Start 130,162,459 bp[1]
End 130,165,740 bp[1]
RNA expression pattern
PBB GE FZD10 219764 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007197

NM_175284

RefSeq (protein)

NP_009128

NP_780493

Location (UCSC) Chr 12: 130.16 – 130.17 Mb Chr 12: 128.6 – 128.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.[5][6] FZD10 has also been designated as CD350 (cluster of differentiation 350).

Function[edit]

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111432 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000081683 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Aug 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochemical and Biophysical Research Communications. 262 (1): 39–43. PMID 10448064. doi:10.1006/bbrc.1999.1161. 
  6. ^ a b "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.