From Wikipedia, the free encyclopedia
Jump to: navigation, search
Frizzled class receptor 3
Symbols FZD3 ; Fz-3
External IDs OMIM606143 MGI108476 HomoloGene23004 IUPHAR: 231 GeneCards: FZD3 Gene
RNA expression pattern
PBB GE FZD3 219683 at tn.png
More reference expression data
Species Human Mouse
Entrez 7976 14365
Ensembl ENSG00000104290 ENSMUSG00000007989
UniProt Q9NPG1 Q61086
RefSeq (mRNA) NM_017412 NM_021458
RefSeq (protein) NP_059108 NP_067433
Location (UCSC) Chr 8:
28.49 – 28.57 Mb
Chr 14:
65.2 – 65.26 Mb
PubMed search [1] [2]

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]


This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[3]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[4][5]

See also[edit]


  1. ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673. 
  2. ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558. 
  3. ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)". 
  4. ^ Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548. 
  5. ^ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A 111 (29): E3005–14. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694. 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.