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Frizzled class receptor 5
Symbols FZD5 ; C2orf31; HFZ5
External IDs OMIM601723 MGI108571 HomoloGene2590 IUPHAR: 233 GeneCards: FZD5 Gene
RNA expression pattern
PBB GE FZD5 206136 at tn.png
More reference expression data
Species Human Mouse
Entrez 7855 14367
Ensembl ENSG00000163251 ENSMUSG00000045005
UniProt Q13467 Q9EQD0
RefSeq (mRNA) NM_003468 NM_001033193
RefSeq (protein) NP_003459 NP_001036124
Location (UCSC) Chr 2:
207.76 – 207.77 Mb
Chr 1:
64.73 – 64.74 Mb
PubMed search [1] [2]

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3]

See also[edit]


  1. ^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800. 
  2. ^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929. 
  3. ^ a b "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)". 

External links[edit]

  • "Frizzled Receptors: FZD5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.