FZD6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FZD6
Identifiers
Aliases FZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6
External IDs MGI: 108474 HomoloGene: 2617 GeneCards: 8323
RNA expression pattern
PBB GE FZD6 203987 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164615
NM_001164616
NM_003506
NM_001317796

NM_001162494
NM_008056

RefSeq (protein)

NP_001155966.1
NP_032082.3

Location (UCSC) Chr 8: 103.3 – 103.33 Mb Chr 15: 39.01 – 39.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[3][4][5]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[5] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[6]

Interactions[edit]

FZD6 has been shown to interact with Secreted frizzled-related protein 1.[7]

See also[edit]

Model organisms[edit]

Model organisms have been used in the study of FXYD3 function. In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[8] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks. A conditional knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[9] Male and female animals underwent a standardized phenotypic screen[10] to determine the effects of deletion.[11][12][13][14] Additional screens performed: - In-depth immunological phenotyping[15]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858. 
  4. ^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478. 
  5. ^ a b "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)". 
  6. ^ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686. 
  7. ^ Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172. 
  8. ^ "Frizzled6 controls hair patterning in mice". 
  9. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ a b "International Mouse Phenotyping Consortium". 
  11. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410free to read. PMID 21677750. 
  12. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  13. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  14. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207free to read. PMID 23870131. 
  15. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.