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Frizzled class receptor 6
Symbols FZD6 ; FZ-6; FZ6; HFZ6; NDNC10
External IDs OMIM603409 MGI108474 HomoloGene2617 IUPHAR: 234 GeneCards: FZD6 Gene
RNA expression pattern
PBB GE FZD6 203987 at tn.png
More reference expression data
Species Human Mouse
Entrez 8323 14368
Ensembl ENSG00000164930 ENSMUSG00000022297
UniProt O60353 Q61089
RefSeq (mRNA) NM_001164615 NM_001162494
RefSeq (protein) NP_001158087 NP_001155966
Location (UCSC) Chr 8:
103.3 – 103.33 Mb
Chr 15:
39.01 – 39.04 Mb
PubMed search [1] [2]

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[4]


FZD6 has been shown to interact with Secreted frizzled-related protein 1.[5]

See also[edit]

Model organisms[edit]

Model organisms have been used in the study of FXYD3 function. In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[6] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks. A conditional knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]


  1. ^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Mar 1998). "Molecular cloning of human Frizzled-6". Biochem Biophys Res Commun 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858. 
  2. ^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". J Biol Chem 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478. 
  3. ^ a b "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)". 
  4. ^ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD. (Aug 2004). "WNT4 activates the canonical beta-catenin-mediated WNT pathway and binds FZD6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.". Experimental Cell Research 298 (2): 369–387. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686. 
  5. ^ Bafico, A; Gazit A; Pramila T; Finch P W; Yaniv A; Aaronson S A (Jun 1999). "Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling". J. Biol. Chem. (UNITED STATES) 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. ISSN 0021-9258. PMID 10347172. 
  6. ^ "Frizzled6 controls hair patterning in mice". 
  7. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  8. ^ a b "International Mouse Phenotyping Consortium". 
  9. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  10. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  13. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

External links[edit]

  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.