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Available structures
PDB Ortholog search: PDBe RCSB
Aliases FZD7, FzE3, frizzled class receptor 7
External IDs MGI: 108570 HomoloGene: 20751 GeneCards: 8324
RNA expression pattern
PBB GE FZD7 203705 s at tn.png

PBB GE FZD7 203706 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 202.03 – 202.04 Mb Chr 1: 59.48 – 59.49 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[3][4][5]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[5]


FZD7 has been shown to interact with DLG4.[6]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479free to read. PMID 9707618. 
  4. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  5. ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)". 
  6. ^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. Netherlands. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. 

External links[edit]

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.