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Frizzled class receptor 7
Symbols FZD7 ; FzE3
External IDs OMIM603410 MGI108570 HomoloGene20751 IUPHAR: 235 GeneCards: FZD7 Gene
RNA expression pattern
PBB GE FZD7 203706 s at tn.png
PBB GE FZD7 203705 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8324 14369
Ensembl ENSG00000155760 ENSMUSG00000041075
UniProt O75084 Q61090
RefSeq (mRNA) NM_003507 NM_008057
RefSeq (protein) NP_003498 NP_032083
Location (UCSC) Chr 2:
202.03 – 202.04 Mb
Chr 1:
59.48 – 59.49 Mb
PubMed search [1] [2]

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]


FZD7 has been shown to interact with DLG4.[4]

See also[edit]


  1. ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
  2. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  3. ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)". 
  4. ^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. (Netherlands) 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. 

External links[edit]

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.