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Frizzled class receptor 8
Protein FZD8 PDB 1ijy.png
PDB rendering based on 1ijy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FZD8 ; FZ-8; hFZ8
External IDs OMIM606146 MGI108460 HomoloGene40606 IUPHAR: 236 GeneCards: FZD8 Gene
RNA expression pattern
PBB GE FZD8 216587 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8325 14370
Ensembl ENSG00000177283 ENSMUSG00000036904
UniProt Q9H461 Q61091
RefSeq (mRNA) NM_031866 NM_008058
RefSeq (protein) NP_114072 NP_032084
Location (UCSC) Chr 10:
35.64 – 35.64 Mb
Chr 18:
9.21 – 9.22 Mb
PubMed search [1] [2]

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]


This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

See also[edit]


  1. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046. 
  2. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)". 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.