FZD8

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FZD8
Protein FZD8 PDB 1ijy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
RNA expression pattern
PBB GE FZD8 216587 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031866

NM_008058

RefSeq (protein)

NP_114072

NP_032084.2
NP_032084

Location (UCSC) Chr 10: 35.64 – 35.64 Mb Chr 18: 9.21 – 9.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[3][4]

Function[edit]

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046. 
  4. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)". 

Further reading[edit]

External links[edit]

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.