From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
IUPAC name
Other names
3D model (JSmol)
Molar mass 260.371
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Falcarindiol is a polyacetylene found in carrot roots which has antifungal activity.[1][2] Falcarindiol is the main compound responsible for bitterness in carrots.[3] Falcarindiol and other falcarindiol-type polyacetylenes are also found in many other plants of the Apiaceae family, including some commonly used seasonings such as dill and parsley.[4] A variety of bioactivities have been reported so far for falcaridiol and the falcarindiol-type polyacetylenes,[5][6][7] and because of potential health-promoting metabolic effects these compounds are studied as potential nutraceuticals.[8] It is the most-active among several polyynes with potential anticancer activity found in Devil's Club (Oplopanax horridus), a medicinal plant used by many indigenous peoples in Alaska and the Pacific Northwest.[9]

See also[edit]


  1. ^ Garrod, B. (1978). "Cis-heptadeca-1,9-diene-4,6-diyne-3,8-diol, an antifungal polyacetylene from carrot root tissue". Physiological Plant Pathology. 13 (2): 241–246. doi:10.1016/0048-4059(78)90039-5.
  2. ^ Kemp, M. S. (1978). "Falcarindiol: An antifungal polyacetylene from Aegopodium podagraria". Phytochemistry. 17 (5): 1002. doi:10.1016/S0031-9422(00)88669-0.
  3. ^ Czepa, A.; Hofmann, T. (2003). "Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree". Journal of Agricultural and Food Chemistry. 51 (13): 3865–3873. doi:10.1021/jf034085+. PMID 12797757.
  4. ^ Christensen, L. P.; Brandt, K. (2006). "Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis". Journal of Pharmaceutical and Biomedical Analysis. 41 (3): 683–693. doi:10.1016/j.jpba.2006.01.057. PMID 16520011.
  5. ^ Jin, H. R.; Zhao, J.; Zhang, Z.; Liao, Y.; Wang, C. Z.; Huang, W. H.; Li, S. P.; He, T. C.; Yuan, C. S.; Du, W. (2012). "The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress". Cell Death and Disease. 3 (8): e376. doi:10.1038/cddis.2012.122. PMC 3434669. PMID 22914324.
  6. ^ Wyrembek, P.; Negri, R.; Kaczor, P.; Czyżewska, M.; Appendino, G.; Mozrzymas, J. W. (2012). "Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons". Journal of Natural Products. 75 (4): 610–616. doi:10.1021/np2008522. PMID 22432736.
  7. ^ Wang L, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Bauer R, Dirsch VM, Atanasov AG. The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability. Front Pharmacol. 2017 Sep 1;8:596. doi: 10.3389/fphar.2017.00596.
  8. ^ Christensen, L. P. (2011). "Aliphatic C17-Polyacetylenes of the Falcarinol Type as Potential Health Promoting Compounds in Food Plants of the Apiaceae Family". Recent Patents on Food, Nutrition and Agriculture. 3 (1): 64–77. doi:10.2174/2212798411103010064. PMID 21114468.
  9. ^ Sun, S; Du, GJ; Qi, LW; Williams, S; Wang, CZ; Yuan, CS (2010). "Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.)". J. Ethnopharmacol. 132 (1): 280–285. doi:10.1016/j.jep.2010.08.026. PMC 3050531.