Fallopia multiflora

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Fallopia multiflora
Fallopia multiflora leaf.jpg
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Core eudicots
Order: Caryophyllales
Family: Polygonaceae
Genus: Fallopia
Species: F. multiflora
Binomial name
Fallopia multiflora
(Thunb.) Haraldson 1978

Fallopia multiflora (Chinese Knotweed; Chinese: 何首乌; hé shǒu wū) is a species of Fallopia in the buckwheat family native to central and southern China.[3][4]

Fallopia multiflora is also known by its synonym, Polygonum multiflorum, and is very often referred to as such in PubMed.[citation needed]

Fallopia multiflora is a herbaceous perennial vine growing to 2–4 m tall from a woody tuber. The leaves are 3–7 cm long and 2–5 cm broad, broad arrowhead-shaped, with an entire margin. The flowers are 6–7 mm diameter, white or greenish-white, produced on short, dense panicles up to 10–20 cm long in summer to mid autumn. The fruit is an achene 2.5–3 mm long.[3]

Fallopia multiflora is used in traditional Chinese medicine, which regards it as having anti-aging properties.[citation needed]

Another name for Fallopia multiflora is Fo-Ti, the root of which is used to treat greying hair, among other indications.[5]


Fallopia multiflora (syn. Polygonum multiflorum) is mildly hepatotoxic due to the THSG and emodin chemical constituents (not anthraquinones, as previously believed); with a LD50 of over 100g/kg in mice. Processed material is considered considerably safer than raw; however, either is believed safe up to 10 to 30 grams per day for a 60 kg human.[6] Extreme overconsumption can lead to liver damage, liver failure, or toxicity-induced hepatitis.[7][8][9][10]


  1. ^ Tropicos, Fallopia multiflora (Thunb.) Haraldson
  2. ^ The Plant List, Reynoutria multiflora (Thunb.) Moldenke
  3. ^ a b "Fallopia multiflora". Flora of China. 
  4. ^ "Fallopia multiflora". Germplasm Resources Information Network. 
  5. ^ http://www.herbwisdom.com/herb-fo-ti-root.html
  6. ^ |Toxicity of raw and processed roots of Polygonum multiflorum|
  7. ^ Cho, Hyun Chin; Min, Hyun Ju; Ha, Chang Yoon; Kim, Hyun Jin; Kim, Tae Hyo; Jung, Woon-Tae; Lee, Ok Jae; Bae, In-Gyu (2009). "Reactivation of Pulmonary Tuberculosis in a Patient with Polygonum multiflorum Thunb-Induced Hepatitis". Gut and Liver 3 (1): 52–6. doi:10.5009/gnl.2009.3.1.52. PMC 2871557. PMID 20479902. 
  8. ^ Wang, T; Wang, J; Jiang, Z; Zhou, Z; Li, Y; Zhang, L; Zhang, L (2012). "Study on hepatotoxicity of aqueous extracts of Polygonum multiforum in rats after 28-day oral administration-analysis on correlation of cholestasis". Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 37 (10): 1445–50. PMID 22860459. 
  9. ^ Jung, KA; Min, HJ; Yoo, SS; Kim, HJ; Choi, SN; Ha, CY; Kim, HJ; Kim, TH; et al. (2011). "Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb". Gut and liver 5 (4): 493–9. doi:10.5009/gnl.2011.5.4.493. PMC 3240794. PMID 22195249. 
  10. ^ Cárdenas, A; Restrepo, JC; Sierra, F; Correa, G (2006). "Acute hepatitis due to shen-min: A herbal product derived from Polygonum multiflorum". Journal of clinical gastroenterology 40 (7): 629–32. doi:10.1097/00004836-200608000-00014. PMID 16917407. 

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