Familial exudative vitreoretinopathy

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Familial exudative vitreoretinopathy
Synonyms Criswick-Schepens syndrome
Three Main Layers of the Eye.png
Retina(located at top of diagram)
Specialty Neurology Edit this on Wikidata

Familial exudative vitreoretinopathy (FEVR) (/ˈfvər/ FEE-vər) is a genetic disorder affecting the growth and development of blood vessels in the retina of the eye.[1] This disease can lead to visual impairment and sometimes complete blindness in one or both eyes. FEVR is characterized by exudative leakage and hemorrhage of the blood vessels in the retina, along with incomplete vascularization of the peripheral retina. The disease process can lead to retinal folds, tears, and detachments.


Genetic types include:

Type OMIM Gene Locus
EVR1 133780 FZD4 11q14-q21
EVR2 305390 NDP Xp11.4
EVR3 605750 ? (exact gene unknown) 11p13-p12
EVR4 601813 LRP5 11q13.4
EVR5 613310 TSPAN12 7q31


External links[edit]

External resources