Like many Farm to Market Roads in the Dallas-Fort Worth Metroplex, little of it is rural due to rapid growth of the region, although it was such when it was designated. It is entirely surface route, much of it divided carriageway.
FM 544 was designated in 1945 from SH 78 at Wylie to Plano. In 1948, FM 544 extended west to SH 289 at Shepton. In 1951, FM 544 extended west to SH 121, replacing FM 1383 from SH 121 east 6 miles. In 1959, FM 544 extended south to the Dallas County Line. In 1978, the section from FM 544 from FM 3412 south to existing FM 544 was transferred to FM 1378, and the section of FM 544 from FM 1378 to SH 78 was renumbered as FM 3412. Existing FM 3412 became a rerouting of FM 544. In 1994, FM 544 extended west from old SH 121(now FM 2281) to current SH 121. In 1995, FM 544 became an urban road. In 2000, the section of FM 544 from SH 78 to the Dallas County line was removed from the state highway system and given to the city of Wylie.