Fatty acid-binding protein
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs is intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.
Members of this family include:
|Protein name||Gene||Tissue distribution||Comment|
|FABP 3||FABP3||muscle and heart||mammary-derived growth inhibitor|
|FABP 8||PMP2||peripheral nervous system||peripheral myelin protein 2|
|FABP 11||fabp11||restricted to fishes|
|FABP 12||FABP12||presence shown in human retinoblastoma cell lines, rodent retina and testis.|
|FABP 5-like 1||FABP5L1|
|FABP 5-like 2||FABP5L2|
|FABP 5-like 3||FABP5L3|
|FABP 5-like 4||FABP5L4|
|FABP 5-like 5||FABP5L5|
|FABP 5-like 6||FABP5L6|
|FABP 5-like 7||FABP5L7|
- Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". Journal of Applied Genetics. 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607.
- Smathers RL, Petersen DR (March 2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Human Genomics. 5 (3): 170–91. doi:10.1186/1479-7364-5-3-170. PMC . PMID 21504868.
- Weisiger RA (October 2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Molecular and Cellular Biochemistry. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
- Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (July 2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Molecular and Cellular Biology. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC . PMID 12077340.
- Deutsch DG (2016-10-13). "A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)". Frontiers in Pharmacology. 7: 370. doi:10.3389/fphar.2016.00370. PMC . PMID 27790143.
- Elmes MW, Kaczocha M, Berger WT, Leung K, Ralph BP, Wang L, Sweeney JM, Miyauchi JT, Tsirka SE, Ojima I, Deutsch DG (April 2015). "Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD)". The Journal of Biological Chemistry. 290 (14): 8711–21. doi:10.1074/jbc.M114.618447. PMC . PMID 25666611.
- Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (August 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Molecular and Cellular Biochemistry. 198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880.
- Liu RZ, Li X, Godbout R (December 2008). "A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis". Genomics. 92 (6): 436–45. doi:10.1016/j.ygeno.2008.08.003. PMID 18786628.
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