Heme ligase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Heme ligase
Identifiers
EC number 4.99.1.8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).[1] This enzyme catalyses the following chemical reaction

2 ferriprotoporphyrin IX beta-hematin

This heme detoxifying enzyme is found in Plasmodium parasites.

References[edit]

  1. ^ Jani, D.; Nagarkatti, R.; Beatty, W.; Angel, R.; Slebodnick, C.; Andersen, J.; Kumar, S.; Rathore, D. (2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathog. 4: e1000053–e1000053. doi:10.1371/journal.ppat.1000053. PMC 2291572Freely accessible. PMID 18437218. 

External links[edit]